مقالات ثبت شده 2023
Hyaluronic Acid Gel Incorporating Curcumin-Phospholipid Complex Nanoparticles Prevents Postoperative Peritoneal Adhesion
Hyaluronic Acid Gel Incorporating Curcumin-Phospholipid Complex Nanoparticles Prevents Postoperative Peritoneal Adhesion
ISSN
0022-3549 , 1520-6017
Journal
pharmaceutical sciences. , 2023, Vol.112(2), p.587-598
Abstract
Peritoneal adhesions following abdominal procedures remain a major surgical issue. This study aimed to evaluate the preventive effect of curcumin-soybean phosphatidylcholine (CUR-SPC) complex-loaded nanoparticles (NPs) embedded in hyaluronic acid (HA) gel. CUR-SPC complex, CUR-SPC NPs, and CUR-SPC-HA gel were fully characterized regarding particle size, zeta potential, morphology, XRD, FTIR, in-vitro release, and rheology. The in vivo efficacy was investigated in a rat model of cecum abrasion and...
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